Ahmad Reza Mehdipour

Assistant professor (EA17)
+32 (0)9 264 65 64
​​​​​Tech Lane Ghent Science Park, Campus Ardoyen
Technologiepark 46, 9052 Zwijnaarde, Belgium
Office n°025

Research interests

Computational structural biology of membrane protein

Protein-ligand interaction

Protein-lipid interaction

Computational glycobiology

Structured-based drug design



Ahmad Reza Mehdipour is a tenure-track assistant professor at the Department of Applied Physics (TW17) and Center for Molecular Modeling (CMM). He is a theoretical biophysicist with a background in pharmacy and computational structural biology. He is also an experienced researcher in various subjects of medicinal chemistry, structural bioinformatics, and computational pharmacology.



2015-2021.    Postdoctoral Fellow

Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt, Germany

2010-2015.     Ph.D.

Faculty of Chemistry, Biochemistry, and Pharmacy, Goethe University Frankfurt, Germany

Computational Structural Biology Group, Max Planck Institute of Biophysics, Frankfurt, Germany

2000-2007.     Pharm.D.

Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran


Selected publications (non-CMM):

  1. Mehdipour AR#, Hummer G#. Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike. PNAS, 2021, 118, e2100425118. (# Corresponding authors).
  2. Hofmann S*, Januliene D*, Mehdipour AR*, Thomas C, Stefan E, Brüchert S, Kuhn BT, Geertsma ER, Hummer G, Tampé R, Moeller A. Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature. 2019, 571, 580-583. (* Sharing first co-authorship)  
  3. Perez C*, Mehdipour AR*, Hummer G, Locher KP. Structure of outward-facing PglK and molecular dynamics of lipid-linked oligosaccharide recognition and translocation. Structure. 2019, 27, 669-678. (* Sharing first co-authorship) 
  4. Mehdipour AR, Hummer G. Cardiolipin puts the seal on ATP synthase. PNAS. 2016,113, 8568-8570.
  5. Perez C*, Faust B*, Mehdipour AR*, Francesconi KR, Forrest LR, Ziegler C. Substrate bound outward-open state of the symporter BetP: insights into Na+ and substrate coupling. Nat Commun. 2014, 15, 4231. (Sharing first co-authorship)
  6. Hemmateenejad B, Yousefinejad S, Mehdipour AR. Novel amino acids indices based on quantum topological molecular similarity and their application to QSAR study of peptides. Amino Acids, 2011, 40, 1169-1183.
  7. Mehdipour AR, Hamidi M. Brain drug targeting: A computational approach for overcoming blood brain barrier. Drug Disc Today. 2009, 14, 1030-1036.
  8. Edarki N, Mehdipour AR, Khoshneviszadeh M, Miri R. Dihydropyridines: evaluation of their current and future pharmacological applications. Drug Disc Today, 2009, 14, 1058-1066.
  9. Mehdipour AR, Javidnia K, Hemmateenejad H, Amirghofran Z, Miri R. Dihydropyridine derivatives to overcome atypical multidrug resistance: design, synthesis, QSAR studies and evaluation of their cytotoxic and pharmacological activities. Chem Biol Drug Des, 2007, 70, 337-346.

A1 Publications



Evidence for a trap-and-flip mechanism in a proton-dependent lipid transporter , E. Lambert, A. R. Mehdipour, A. Schmidt, G. Hummer, C. Perez , Nature Communications , Volume 13, issue 1, article number 1022 , 2022 , IF: 15.805 , 4/72 [Q1]

Other Publications

Keynote / Plenary / Invited talks